To explore whether RACK1 could be an important factor in the development and progression of glioma, we first evaluated its mRNA expression level in glioma tissues (n = 173) and normal brain tissues (n = 20) by RT-PCR, discovering that RACK1 expression was statistically up-regulated in glioma tissues compared with normal brain tissues (Figure 1A, ** p < 0.01). This evidence concerns the gene RACK1 and central nervous system cancer.