As shown in Figure 6C, we found that the expression levels of MMP‐2, MMP‐9, ZEB1, N-cadherin, and Integrin β1 significantly diminished in the siRNA1-RACK1 and siRNA2-RACK1 groups, suggesting that siRNA-RACK1 might suppress migration and invasion of malignant glioma cells by inhibiting the EMT signaling pathway. Here, ZEB1 is linked to malignant glioma.