Thus, because increased escape latency and reduced percentage of path in the target quadrant both indicate cognitive deficits, lower SUVrs should point to serious cognitive impairment while higher SUVrs indicate mild impairment in APP/PS1 mice, suggesting that hippocampal FDG uptake can be an indicator of the progression in Alzheimer’s cognition, at least in animals. The gene discussed is PSEN1; the disease is Cognitive impairment.