INS and type 2 diabetes mellitus: Previous studies also demonstrate that miR-195 and miR-15b are both increased in the livers of obese T2DM model animals, accompanied by the downregulation of INSR, and further analysis confirms the direct binding of these miRNAs to the 3′-UTR of INSR, resulting in impairment of insulin signaling in hepatocytes [39,40].