Though the percentages of CD19+ B cells, CD19+CD24+CD38+ B cells, and CD19+ CD24+ CD38+ PD-L1+ B cells were not significantly different in terms of tumor grades, lymph node metastasis, ER, PR, and HER2 status, a tight correlation was seen between upregulated expression of PD-L1 on CD19+CD24+CD38+ Bregs and higher TNM phases of IBCa. The gene discussed is CD38; the disease is neoplasm.