Subsequent analysis shows that neurons cultured from hMMP-1 Tg animals have significantly increased number of intersections from 0 μm to 90 μm from cell soma when compared to hMMP-1 Tg + SCH, WT + SCH, and WT + DMSO groups (Fig. 8a,b,c) (MMP-1 Tg + DMSO n = 20 neurons, MMP-1 Tg + SCH n = 20 neurons, WT + SCH n = 20 neurons, WT + DMSO n = 20 neurons; ANOVA with Dunnett’s post-tests, p value ≤ 0.01). The gene discussed is MMP1; the disease is spindle cell hemangioma.