Importantly, emerging evidence strongly suggests that PRR act together or with other cell surface receptors to initiate and amplify signalling in atherosclerosis as illustrated by the non-redundant role of the oxLDL-binding type B scavenger receptor CD36 in coordinating NLRP3 activation and TLR4/6 assembly23, 24. The gene discussed is TLR4; the disease is atherosclerosis.