Studies of TNF-α/IL-10 ratio in humans found that this ratio is attenuated following live rubella vaccine challenge among children (30), is elevated in the plasma of acute myocardial infarction patients compared to matched healthy control (31), and is associated with hyperglycemic states in placental tissues, with type 2 diabetes mellitus patients having the highest level (32). The gene discussed is TNF; the disease is acute myocardial infarction.