Diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance in skeletal muscle, liver and adipose tissues with a failure of b-cell compensation and a relative insulin deficiency (Association 2013 ▶; Pettitt et al. 2014 ▶). The gene discussed is INS; the disease is Other metabolic disease.