A meta-analysis of over 4000 bone marrow aspirates from breast cancer patients without bone metastases found that premenopausal patients had a significantly higher prevalence of bone marrow disseminated tumour cells (DTCs) than postmenopausal women (32.7% vs 29.5%) [21], suggesting premenopausal bone (with low activin levels due to ovarian inhibin) may attract tumour cells. Here, INHBE is linked to neoplasm.