Developing therapeutic modalities that induce remission in the remaining patients is important in the treatment of IBD and the combination of 5-aminosalicylic acid derivatives and corticosteroids, such as prednisolone, immunomodulators, such as azathioprine and 6-mercaptopurine, or TNF-α antibody drugs, such as infliximab, is used. The gene discussed is TNF; the disease is inflammatory bowel disease.