CASP8 and acute myeloid leukemia: In acute myeloid leukemia (AML) cells, NOB induces cell cycle arrest at the G0/G1 phase through downregulating ERK signaling pathway, increases cell apoptosis through activation of caspase-3, caspase-9, and caspase-8, and upregulates of MAPK signaling pathway in HL-60 cell line.