To approach our aims, we selected a Tet-On Aβ42-GFP SH-SY5Y cell model and a APP/PS1/Tau triple transgenic AD (3× Tg-AD) mouse model to assess the beneficial use of the herbal formula B401 in complimentary or integrated therapy for neuroprotective and neuropsychiatric remission in AD. The gene discussed is APP; the disease is Alzheimer disease.