As shown in Figure 4(b)(B), quantified brain BDNF expression levels of 3× Tg-AD mice were significantly decreased compared to those of non-AD mice (P < 0.01), while quantified brain BDNF expression levels of 3× Tg-AD mice with B401 treatment were significantly increased compared to those of 3× Tg-AD mice with sham treatment (P < 0.01). The gene discussed is BDNF; the disease is Alzheimer disease.