SOD2 and Alzheimer disease: Quantified SOD2 levels in 3× Tg-AD mice with sham treatment were significantly reduced compared to those of 3× Tg-AD mice with B401 treatment and their control of non-AD mice (Figure 6(d)(B), P < 0.01), even though quantified SOD2 levels of 3× Tg-AD mice with B401 treatment were significantly reduced compared to those of non-AD mice (Figure 6(d)(B), P < 0.01).