Unlike results of 3× Tg-AD mice with sham treatment, we observed that IHC staining expressions of Aβ, phosphorylated Tau, and NFTs became indistinct in CA1 and DG areas of 3× Tg-AD mice with B401 treatment (Figures 7(a)(B), 8(a)(B), and 9(a)(B)). Here, MAPT is linked to Alzheimer disease.