Previous studies have shown that MIIP inhibits glioma cell migration and invasion through two mechanisms: (1) attenuating insulin-like growth factor-binding protein 2 (IGFBP2)-mediated cell migration [10] and (2) blocking HDAC6 activity and increasing acetylated α-tubulin, which stabilizes microtubules [11]. This evidence concerns the gene IGFBP2 and central nervous system cancer.