Also included are breast cancer susceptibility proteins, such as BRCA1 (FANCS) and BRCA2 (FANCD1) (Howlett et al., 2002; Park et al., 2014b; Sawyer et al., 2015), and SLX4 (FANCP), a scaffold for endonucleases such as XPF (FANCQ) (Kim et al., 2011; Stoepker et al., 2011). The gene discussed is ERCC4; the disease is breast carcinoma.