Univariate analyses showed that diabetes (OR = 3.19, P = 0.005), regular hemodialysis (OR = 6.46, P < 0.001), higher heart rate (OR = 1.04, P = 0.02), lower hemoglobin level (OR = 0.53, P < 0.001), higher creatinine level (OR = 1.27, P = 0.001), higher CRP level (OR = 1.67, P = 0.001), absence of statin treatment (OR = 0.37, P = 0.02), lower ankle DBP (OR = 0.97, P = 0.007), higher ankle PP (OR = 1.03, P = 0.001), and higher AHI (OR = 1.06, P < 0.001) were significantly associated with a higher Rutherford grade (Table 3). The gene discussed is CRP; the disease is diabetes mellitus.