AGAP3 and cutaneous mastocytosis: Targeted screening programs are likely to be most efficient among patients with low CD4+ cell count, which is an independent predictor of CrAg positivity [9, 10, 11, 12], In comparison, screening for CM using the current standard methods—including microscopy or fungal culture of cerebrospinal fluid obtained through lumbar puncture or detection of CrAg in body fluids via latex agglutination or enzyme immunoassay may be suboptimal.