FLAER is thought to be able to detect small clones to a level of approximately 0.5%,(17) particularly in cases of severe neutropenia, aplastic anemia (AA) and myelodysplastic syndromes (MDS).(19–21) Replacement of CD55/CD59 with FLAER/CD14 (monocytes) or FLAER/CD24 (neutrophils) in our procedures improved FCM data resolution (Figures 3E and 3H), particularly of small sized clones. The gene discussed is CD55; the disease is myelodysplastic syndrome.