CD40LG and hepatitis C virus infection: Similarly, another investigation conducted inBrazil in patients with non-A, non-B, non-C hepatitis revealed a low rate of acutehepatitis E (1.5%; 1/64) (dos Santos et al. 2010).On the other hand, anti-HEV IgM was detected in 27 out 552 (4.9%) samples from patientsclinically suspected of hepatitis E analysed between the years 2006-2013 (Passos-Castilho et al. 2015).