Conversely, a pilot study by De Loor et al. demonstrated that the urinary concentrations of YKL-40 and NGAL in ICU patients with AKI stage ≥ 2 measured within 12 h or 24 h exhibited higher convergent diagnostic performance than did serum YKL-40, which did not show any predictive power against AKI.37 The gene discussed is LCN2; the disease is acute kidney injury.