Some nucleotide variants (rs2736108 upstream of hTERT, rs7705526 in intron 2 of hTERT, and rs12696304 downstream of TERC) were associated with telomere length in leukocytes.[5,6] Some intronic variants (rs10069690, rs2242652, and rs7725218) of hTERT have been reported to have association with hTERT expression in prostate cancers.[7] This study aimed to identify nucleotide variants associated with mRNA expression of hTERT and TERC through genome-wide analysis. The gene discussed is TERC; the disease is Familial prostate cancer.