CD44 and neoplasm: As shown in Figs. 2 and 3 and Table 2, overexpression of CD44 is associated with Lauren type (intestinal type) (OR, 1.53 [95% CI, 1.02–2.30]; P = 0.038) and LI (OR, 1.36 [95% CI, 1.06–1.76]; P = 0.021) rather than gender, age, tumor location, differentiation type, TNM stage, depth of invasion, LN, VI, and distant metastasis (all P > 0.05).