These results are consistent with (a) enhanced nuclear YAP and increased Ki67-positive proliferating cells in vivo, (b) increased YAP oncogenic activity including the induction of growth factors expression such as CTGF and the initiation of EMT process observed in vitro and (c) the positive correlation between high MG-adducts detection and nuclear YAP in human primary mammary tumors, thus supporting the clinical relevance of our findings. Here, CCN2 is linked to breast cancer.