TP53 and neoplasm: To further validate the possible function of p53 exon-6 truncations and p53-psi in regulating the MPTP function, we performed similar experiments in tumor-derived cell lines with p53-psi splicing mutation (Hop62), exon-6 truncating mutation (SW684, DMS114 and Calu-6), p53-WT (A549, MCF7), a shorter truncation (H2126) and a p53 homozygous deletion (H1299) upon knock down of p53.