TP53 and neoplasm: Figure 5E and F show that the inactivation of CypD expression in xenograft models using an inducible CRISPR-Cas9 gene editing system decreased the tumor volume of p53 exon-6 truncating mutant-expressing cells (Calu6), but not the tumor volume of p53-WT expressing cells (A549) (Figure 5—figure supplement 2).