Furthermore, osteopontin null mice showed similar metabolic and adipose tissue phenotype, i.e., protection from developing insulin resistance, reduced inflammation of WAT, and reduced collagen content in WAT, however, in comparison to FXIII-A null mice, osteopontin deficient mice did not gain weight on HFD and showed no adipocyte hypertrophy48, 49, 50. Here, SPP1 is linked to Insulin resistance.