ABCB11 and Fulminant hepatic failure: A notable example is the case of troglitazone, which was withdrawn from the market after reports of fulminant hepatic failure, for which later evidence was provided that the major metabolite troglitazone sulfate and to a lesser extent the parent drug troglitazone could pose cholestatic toxicity by interference with hepatobiliary transport and inhibition of the bile salt export pump (BSEP), thereby potentially contributing to troglitazone-induced liver injuries in humans3, 4.