Importantly, we demonstrate that SRA is induced in the livers of obesity after fasting (Fig. 3a), and that the hepatic levels of SRA and ATGL are inversely correlated in WT-Chow, WT-HFD and ob/ob mice (Fig. 3a,b). This evidence concerns the gene PNPLA2 and obesity due to melanocortin 4 receptor deficiency.