The Pnpla3 deletion in mice does not affect liver TAG content even under high-sucrose or high-fat diet conditions (Chen et al., 2010; Basantani et al., 2011) and human PNPLA3 overexpression in mice does not decrease liver steatosis (Li et al., 2012). The gene discussed is PNPLA3; the disease is Hepatic steatosis.