SREBF1 and metabolic dysfunction-associated steatotic liver disease: A low plasma level of dehydroepiandrosterone sulfate (DHEA-S), a kind of proandrogen, is associated with advanced NAFLD (Charlton et al., 2008) Dehydroepiandrosterone (DHEA) supplementation of a high-fat plus fructose diet reduced the induction of SREBP-1c and insulin resistance in mice, and protected against steatosis (Aragno et al., 2009).