BCR and chronic myelogenous leukemia, BCR-ABL1 positive: We therefore investigated the ability of BSP to inhibit the clonogenic growth and proliferation of two acute myeloid leukemia (AML) cell lines (MV4;11 and KASUMI-1), the hyperdiploid AML line OCI-AML3, and the BCR-ABL–positive chronic myeloid leukemia (CML) cell line K562, and we observed growth inhibition in the concentration range 100 to 500 nM (Fig. 3A and fig.