A significant association was observed between common variants of TRPM6 and hypomagnesemia (Hruby et al. 2013; Meyer et al. 2010), with a specific T allele of rs11144134 in TRPM6 associated with higher femoral neck and lumbar spine BMD (Meyer et al. 2010). This evidence concerns the gene TRPM6 and familial primary hypomagnesemia.