CDK2 and osteoarthritis: Moreover, Nakamachi et al. found that miR-124 level significantly decreased in RA synoviocytes as compared with osteoarthritis (OA) synoviocytes, and miR-124 could target cyclin-dependent kinase 2 (CDK2) or monocyte chemotactic protein 1 (MCP1), adjusting proliferation and the ability to produce chemokines of fibroblast-like synovial cells (43).