HLA-C and familial dilated cardiomyopathy: Given that the TnT-mediated function is dependent on the myosin heavy chain (MHC) isoform (Ford et al., 2012; Chandra et al., 2015; Gollapudi et al., 2015; Gollapudi and Chandra, 2016), we hypothesized that the effects of DCM-linked mutations in TnT on contractile dynamics would be differently modulated by α- and β-MHC.