LRRK2 and Parkinson disease: Other studies also suggest the involvement of CHIP in regulating the levels of other Hsp90 client proteins such as runt-related transcription factor 1 (Runx1) and LRRK2, via UPS, a protein whose mutation is linked to Parkinson’s disease (Ding and Goldberg, 2009; Shang et al., 2009).