The cytoplasmic CHIP does not only take care of cytoplasmic proteins, but is also involved in the ubiquitination and degradation of mitochondrial proteins like leucine-rich repeat kinase 2 (LRRK2), a mutation in which has largely been implicated in the onset of many cases of familial Parkinson’s disease (Ding and Goldberg, 2009). This evidence concerns the gene STUB1 and Parkinson disease.