No connection between DN and altered levels of PROM1 has previously been reported to our knowledge, but in a STZ mouse model of retinal vasculopathy and neuropathy, also secondary complications to diabetes, PROM1 in the photoreceptors was shown to be destroyed by metalloprotease (MMP)-9 whereas no retinopathy or neuropathy was seen in MMP-9 knockout mice [32]. Here, PROM1 is linked to neuropathy.