Both for REVERBA and REVERBB, 24-hour circadian rhythmicity was observed in athletes, lean sedentary and obese subjects (Fig. 2A, JTK_CYCLE p < 0.001), but the rhythm was dampened in type 2 diabetes patients (Fig. 2A, JTK_CYCLE p > 0.05). This evidence concerns the gene NR1D2 and type 2 diabetes mellitus.