For REVERBB, highest expression was determined at 24 h and at 48 h, and lowest expression at 16 h, 36 h and 56 h (Fig. 2A) in all groups except for type 2 diabetes patients (ANOVA TL, UL, OB: p < 0.001, T2D: p = 0.473). This evidence concerns the gene NR1D2 and type 2 diabetes mellitus.