The innate immune resistance refers to the finding from certain lymphomas and gliomas that the PD-L1 expression is up-regulated by constitutive oncogenic signaling in the tumor cells, including the PI3K-Akt pathway and constitutive anaplastic lymphoma kinase (ALK) signaling, both independent of inflammatory signals from the tumor microenvironment [48, 49]. This evidence concerns the gene CD274 and central nervous system cancer.