TMPRSS2 and Familial prostate cancer: Other genomic alterations common to prostate cancer were also detected, including alterations in genes involved in homologous recombination repair (i.e. BRCA2, CHEK2) (N = 2), androgen receptor (AR) (N = 1), TMPRSS2:ERG rearrangements (N = 3) and alteration in the PI3K/Akt/mTOR signaling pathway (N = 5) (Table 2).