On the contrary, the far-upstream element (FUSE)-binding protein-interacting repressor (FIR), splicing variant of PUF60 lacking exon5, have been reported to be overexpressed in various malignant tumors, such as colorectal cancers [2, 3], hepatocellular carcinomas [4, 5], T-cell acute lymphoblastic leukemia [6],and non-small cell lung cancer [7]. This evidence concerns the gene PUF60 and hepatocellular carcinoma.