VEGFA and glioblastoma: As an anti-VEGF monoclonal antibody, bevacizumab (Avastin) was approved for treatment of metastatic colorectal cancer (mCRC), metastatic breast cancer(MBC), metastatic non-small cell lung cancer (NSCLC), metastatic renal cell cancer (RCC), and glioblastoma multiforme (GBM) by the Food and Drug Administration [1].