In summary, the present study demonstrated that MTE could inhibit the proliferation and induce the apoptosis of Jurkat cells and T-ALL cells, which mediated by PTEN/PI3K/AKT/mTOR signaling pathways.Our results revealed the novel effects of MTE on leukemia therapy and provided experimental evidences on the detailed mechanism. This evidence concerns the gene PTEN and acute lymphoblastic leukemia.