SOD1 and melanoma: To counteract the potential damaging effects of high ROS/NO concentrations (DNA damage, mutations, induction of apoptosis), melanoma cells have acquired efficient antioxidant strategies, based on overexpressed catalase and SOD imbedded in the membrane close to NOX1 [17], the remaining ROS (after catalase and SOD action) has a stimulating effect for proliferation of tumor cells.