TIMP3 and aneurysm: It has recently been reported that miR-181b can regulate nuclear factor-κB–mediated activation of endothelial cells and ensuing vascular inflammation.61 However, effects on atherosclerosis and aneurysm were not assessed, although the authors did demonstrate that miR-181b overexpression in endothelial cells dramatically suppressed TIMP-3 expression.61 It is also plausible that other miRs can regulate TIMP-3 expression in atherosclerosis and aneurysms, affecting disease development.