Indeed, inhibition of miR-712 (or its human homologue miR-205) prevented endothelial inflammation and atherosclerosis in a carotid ligation model34 and aortic dilatation, elastin fragmentation, and aortic rupture in Apoe−/− mice,62 potentially through post-transcriptional regulation of TIMP-3 and associated heightened MMP activity. This evidence concerns the gene ELN and atherosclerosis.