Other differences noted included the following: decreased AAA severity (Figure 4C), lowered abdominal aortic miR-181b expression by quantitative polymerase chain reaction (40%; Figure 4D), increased TIMP-3 protein expression (Figure 4E), significantly smaller mean maximal abdominal aortic diameters from histology (Figure 4F and 4G), and markedly more elastin (Figure 4G and 4H). This evidence concerns the gene ELN and triple-A syndrome.