A more specific metastasis suppressive role has been described for the (NAD)+‐dependent HDAC SIRT6 in pancreatic ductal adenocarcinoma (Kugel et al., 2016); the effects of SIRT6 loss seem to be largely mediated through induction of the RNA‐binding protein Lin28b. This evidence concerns the gene SIRT6 and pancreatic ductal adenocarcinoma.