Additionally, lncRNA BCAR4 controls the epigenetic regulation of Hedgehog/GLI2 transcriptional activation in support of breast cancer progression (Xing et al., 2014), whereas CCAT2 modulates WNT and MYC activity in colon cancer leading to increased metastasis (Ling et al., 2013) (Fig. 3C). Here, MYC is linked to breast cancer.