In T‐cell acute lymphoblastic leukemia (T‐ALL), specific non‐coding mutations upstream of the TAL1 oncogene are capable of generating a self‐sustaining transcriptional loop, which involves several T‐ALL transcription factors such as MYB, GATA3, RUNX1 and TAL1 itself (Mansour et al., 2014). This evidence concerns the gene GATA3 and acute lymphoblastic leukemia.