In T‐cell acute lymphoblastic leukemia (T‐ALL), specific non‐coding mutations upstream of the TAL1 oncogene are capable of generating a self‐sustaining transcriptional loop, which involves several T‐ALL transcription factors such as MYB, GATA3, RUNX1 and TAL1 itself (Mansour et al., 2014). Here, RUNX1 is linked to acute lymphoblastic leukemia.