Further stratification of ER-positive cancers according to nodal status showed that high KI67 was associated with worse survival in both node-negative and node-positive cancers in multivariate analysis (node-negative 2.47 (1.16–5.27); node-positive 1.74 (1.05–2.86); P-heterogeneity = 0.67) (Table 2). Here, MKI67 is linked to cancer.