The LRP transcript level was significantly higher in both CIS-resistant cell lines A2780CR1, and A2780CR2 (P < 0.05 and P < 0.01, respectively), both TOP-resistant cell lines (P < 0.01) and both PAC-resistant cell lines A2780PR1 and A2780PR2 (P < 0.01 and P < 0.05, respectively) (Fig. 2e), however the increase was not very high. The gene discussed is MVP; the disease is in situ carcinoma.