GAD1 and nervous system disorder: Our patient fulfilled the clinical criteria of SPS which includes (1) muscular rigidity in limbs and axial muscles; (2) continuous co-contraction of agonist and antagonist muscles; (3) episodic spasms precipitated by unexpected noises, tactile stimuli or emotional upset; (4) absence of any other neurological disease that could explain stiffness and rigidity; and (5) presence of anti-GAD antibodies (GAD-Abs) in serum [7].