This revealed tumour site associated shared sequence variants in 1) APC, PDGFRA, PTEN for primary colon and/or rectal tumours, 2) ATM, TP53 for synchronous liver metastases, 3) FGFR3 and TP53 for metachronous liver metastases, 4) ABL1, APC, ATM, ERBB4 and SMAD4 for synchronous lung metastases, and 5) APC and TP53 for metachronous lung metastases (Table 4). The gene discussed is ERBB4; the disease is rectal neoplasm.