To address this, we overexpressed MT1-MMP in MCF-7 breast cancer cells, which represent early stage breast cancer [32] and are naturally MT1-MMP deficient [33, 34], and for these reasons are commonly used by others to understand the effects of MT1-MMP overexpression [21, 24, 25, 27, 28]. The gene discussed is MMP14; the disease is breast cancer.