SMPD1 and cancer: In this study we investigated for the first time the role of LC fruit extract in aSMase modulation, and found inhibition of aSMase activity, saving of very low fatty acid (FA) SM, decrease of saturated/unsaturated FA SM, over-expression of GLRX2 and RNF7 anti-apoptotic genes and inhibition of PTGS1 cancer gene.