We further demonstrated that the time-dependent phosphorylation of EGFR in response to SC19 infection became attenuated in sh-ErbB3 transfected cells (Fig. 3f), and vice versa, 5 μM AG1478 treatment significantly blocked the infection-induced phosphorylation of ErbB3, compared with the vehicle control (Fig. 3g). Here, EGFR is linked to infection.