Apart from angiogenesis (e.g. via vascular endothelial growth factor, VEGF), HIFs promote a number of processes known to foster tumor development, including inflammation (e.g. via the NF-κB pathway), a shift to glycolysis (Warburg effect, e.g. via up-regulation of glucose transporter), invasive behavior (e.g. via Twist, an inducer of the epithelial-mesenchymal transition), and malignant potential (e.g. via OCT4 and other genes promoting a stem cell phenotype). The gene discussed is VEGFA; the disease is neoplasm.